Relationship between gut microbiota dysbiosis and bile acid in patients with hepatitis B-induced cirrhosis
- Published on 21/10/2025
- Reading time: 5 min.
Li Yannan 1,2, Zhang Dan 3, Tian Tian 3, Xie Jing 3, Wang Xiaolin 3, Deng Wenjun 3, Hao Ningbo 3, Li Changzheng 3
1 https://ror.org/02yd1yr68 The Postgraduate Training Base of Jinzhou Medical University (Characteristic Medical Center of the PLA Rocket Force) Beijing China
2 https://ror.org/01ey7we33 Department of Gastroenterology Daqing Oilfield General Hospital Heilongjiang China
3 https://ror.org/05tf9r976 Department of Gastroenterology Chinese People’s Liberation Army Rocket Force Characteristic Medical Center Beijing China
Abstract
Background Dysbiosis of the gut microbiota is a significant factor influencing the progression of hepatitis B-related cirrhosis (HBC). Bile acid (BA) metabolism is increasingly recognized as a key participant in the liver–gut microbiota axis.
Methods A total of 46 patients with HBC and 33 healthy adults were enrolled in this study. The HBC patients were divided into a BA-normal group and a BA-high group. Fecal samples were collected from patients...
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