Antimicrobial resistance in Vibrio cholerae O1/O139 clinical isolates: a systematic review and meta-analysis
Chaoying Liu a , Ye Wang b , Khalil Azizian c , Nazanin Omidi d , Vahab Hassan Kaviar d , Ebrahim Kouhsari e,f & Abbas Maleki d
a
Zhumadian Academy of Industry Innovation and Development, Huanghuai University, Zhumadian, China
b
School of Biological and Food Processing Engineering, Huanghuai University, Zhumadian, China
c
Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
d
Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran
e
Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
f
Department of Laboratory Sciences, Faculty of Paramedicine, Golestan University of Medical Sciences, Gorgan, Iran
CONTACT Abbas Maleki mailto:abbasmaleki_ilam@yahoo.com Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran
Chaoying Liu mailto:liuchaoying@huanghuai.edu.cn Zhumadian Academy of Industry Innovation and Development, Huanghuai University, Zhumadian
463000, China
Abstract
Objectives
Vibrio choleraeO1/O139 is responsible for cholera epidemics that remains a huge public health menace across the globe. Furthermore, an increasing resistance rate among V. cholerae strains has been reported around the world. Therefore, the objective of this meta-analysis was to evaluate the weighted pooled resistance (WPR) rates in clinical V. cholerae O1/O139 isolates based on different years, areas, antimicrobial susceptibility testing, and resistance rates.
Research design and methods We searched the studies in PubMed, Scopus, Embase, and Web of Science (until January 2020). Statistical analyses were conducted using STATA software (ver. 14.0).
Results A total of 139 studies investigating 24,062 V. cholerae O1/O139 isolates were analyzed. The majority of the studies originated in Asia (n= 102). The WPR rates were as follows: azithromycin 1%, erythromycin 36%, ciprofloxacin 3%, cotrimoxazole 79%, doxycycline 7%, and tetracycline 20%. There was increased resistance to cotrimoxazole, ciprofloxacin, and tetracycline during the 1980–2020 years.
Conclusions Temporal changes in antibiotic resistance rate found in this study demonstrated the critical continuous surveillance of antibiotic resistance. Also, ciprofloxacin, azithromycin, gentamicin, cephalexin, imipenem, ofloxacin, and norfloxacin were found to be the best antibiotics against V. cholera, with the highest and the lowest effectiveness resistance rate.
Keywords: Antimicrobial resistance, V. cholerae O1/O139, systematic review and meta-analysis.
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