Proteomics insights into Zika virus infection
Gabriel do Nascimento Soares a , Yohana Porto Calegari-Alves a , Camila Innocente-Alves a , Sara Luísa Sulzbach a , Ana Luiza Marques a , Karyn Scheffler Schirma Farias a , Aline Martins Faustino a , Lucélia Santi a,b & Walter Orlando Beys-da-Silva a,b,*
a Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
b Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
CONTACT Walter Orlando Beys-da-Silva mailto:walter.beys@ufrgs.br Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752 Suit 707, Porto Alegre, RS 90610-000, Brazil
Abstract
The Zika virus (ZIKV) is an arbovirus that has been associated with small outbreaks in several countries over the past decades. In 2015, ZIKV caused an important outbreak in Brazil that resulted in serious neurological complications, such as Guillain-Barré syndrome and microcephaly in newborns. Proteomics approaches have significantly contributed to understanding the molecular mechanisms underlying ZIKV infection and pathogenesis. This review compiles these studies that explore proteomics methodologies, as well as the main host models, and ZIKV strains, shedding light on crucial aspects of viral infection. The identification of potential biomarkers, metabolic pathways, and molecular processes associated with infection and associated diseases, as well as potential therapeutic targets, are discussed in this article, demonstrating the ongoing potential of proteomics to bridge critical gaps in the molecular understanding of ZIKV infection.
Keywords: ZIKV, Zika virus, virus, proteomics, protein.
Copyright Taylor & Francis Group 2021 powered by GNM Healthcare Consulting Group, LLC
Top articles about Travelers' Health
Search | Advanced search
Articles by topics
My bibliography
Access your favorite articles, annotate and compile them by folders or export them in ENDNOTE format!
