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Time interval distribution of hepatitis B vaccine immunization among infants in China from 2017 to 2021

  • Published on 22/07/2025
  •  Reading time: 1 min.

Sihui Zhang a,b,* , Xiaoling Tian c,* , Li Wang d,* , Ming Liu e,* , Chao Wang b , Tianshuo Zhao a,b , Xianming Cai a,b , Xiyu Zhang a,b , Mingting Wang a,b , Juan Du b , Yaqiong Liu b , Qingbin Lu b , Jiang Wu f,* , Ninghua Huang b,g,h,* & Fuqiang Cui b,g,h

a Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, P. R. China
b Department of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, Beijing, P. R. China
c Institute for Immunization and Prevention, Inner Mongolia Center for Disease Control and Prevention, Hohhot City, People's Republic of China
d Institute for Immunization and Prevention, Suzhou Center for Disease Control and Prevention, Suzhou, China
e Department of Infectious Disease, Guizhou Provincial Center for Disease Control and Prevention, Guiyang, China
f Institute for Immunization and Prevention, Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing, China
g Key Laboratory of Epidemiology of Major Diseases, Ministry of Education, Peking University, Beijing, China
h Center for Infectious Diseases and Policy Research & Global Health and Infectious Diseases Group, Peking University, Beijing, P. R. China

CONTACT Jiang Wu mailto:wj81732@hotmail.com Institute for Immunization and Prevention, Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, No. 16, HePingli Middle Street, DongCheng District, Beijing 100013, China.
Ninghua Huang mailto:hnh@bjmu.edu.cn Department of Laboratorial Science and Technology & Vaccine Research Center, School of Public Health, Peking University, Beijing 100191, P. R. China.

Abstract

Infant hepatitis B vaccine coverage in China is high, with over 95% of infants immunized; however, high vaccine coverage can often mask low timeliness. The vaccination interval between the second and third doses is not clearly defined by immunization guidelines in China. This retrospective cohort study assessed the time interval distribution of hepatitis B vaccination among a cohort of randomly selected live births from the Centers for Disease Control and Prevention across four...

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