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Seroprevalence and Shifting Endemicities of Hepatitis A Virus Infection in Two Different Geographical Areas in the Philippines

  • Published on 22/07/2025
  •  Reading time: 6 min.

Josefina C. Carlos   1 , Vinna Marie T. Quinones 1 , Adriana Guzman-Holst   2  

1 University of the East Ramon Magsaysay Memorial Medical Center, Quezon City, Philippines
2 GSK, Avenue Fleming 20, Wavre, Belgium

Abstract

Introduction Infection with hepatitis A virus (HAV) is often asymptomatic in young children, but most adolescents and adults will have symptoms ranging from nausea and tiredness to acute liver failure and even death. The risk of severe disease is higher in older adults and people with pre-existing liver disease. Immunization is recommended in regions with low HAV endemicity levels, i.e., where people get infected later in life. In the Philippines, recent epidemiologic...

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