Chronic chikungunya disease (CCD): clinical insights, immunopathogenesis, and therapeutic perspectives
- Published on 07/01/2025
- Reading time: 4 min.
Wern Hann Ng, 1,2,3, Kennedy Amaral, 4, Emilie Javelle, 5,6,7,8, Suresh Mahalingam 1,2,3
1 Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University, QLD, 4222, Australia
2 Global Virus Network (GVN) Centre of Excellence in Arboviruses, Griffith University, Gold Coast, QLD, Australia
3 School of Pharmacy and Medical Sciences, Griffith University, Gold Coast, QLD, Australia
4 Federal University of Cariri, Barbalha, Ceará, Brazil
5 Unité parasitologie et entomologie, Département Microbiologie et Maladies Infectieuses, Institut de recherche biomédicale des armées, Marseille, France
6 Aix Marseille Univ, IRD, SSA, AP-HM, VITROME, Marseille, France
7 IHU Méditerranée Infection, Marseille, France
8 Hôpital d'instruction des armées Laveran, Marseille
Joint corresponding authors: Address correspondence to Prof. Suresh Mahalingam, Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University (Gold Coast Campus), Parklands Drive, Southport, Gold Coast, 4222, Queensland, Australia, Phone: +61 7 56780664, email:s.mahalingam@griffith.edu.au or Mr Wern Hann Ng, Emerging Viruses, Inflammation and Therapeutics Group, Menzies Health Institute Queensland, Griffith University (Gold Coast Campus), Parklands Drive, Southport, Gold Coast, 4222, Queensland, Australia, email: wernhann.ng@griffithuni.edu.au
Abstract
Chikungunya virus, an arthropod-borne pathogen is recognised by the World Health Organization as a top priority Emerging Infectious Disease and is ranked fourth in public health needs according to the Coalition for Epidemic Preparedness Innovations (CEPI). Despite its substantial impact, as evidenced by an annual estimate of 120,274 disability-adjusted life years, our understanding of the chronic aspects of chikungunya disease remains limited. This review focuses on Chronic Chikungunya...
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