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Shifting targets: typhoid's transformation from an environmental to a vaccine-preventable disease, 1940–2019

Published on 10/02/2026 |  Original article (Full-text)  | Webster, Emily et al. | The Lancet Infectious Diseases 2024; 24(4): e232-e244 1 min.

160 years after the discovery of its waterborne transmission and 120 years after the development of the first-generation of vaccines, typhoid fever remains a major health threat globally. In this Historical Review, we use WHO's Institutional Repository for Information Sharing to examine changes in typhoid...

 Typhoid
Typhoid conjugate vaccines: is a single dose enough for durable protection?

Published on 10/02/2026 |  Original article (Full-text)  | Vipin M. Vashishtha et al. | Expert Review of Vaccines 2025; 24(1): 194-205 1 min.

Typhoid fever is widespread in developing countries. Most typhoid vaccines have gone into some disrepute for their substantial side effects and low efficacy. The latest typhoid vaccines use Salmonella‘s Vi-capsular polysaccharide (Vi-CPS) conjugated to a protein carrier. The WHO recommends...