Diagnostic performance of hepatitis C virus core antigen testing for detecting hepatitis C in people living with hepatitis B: a systematic review and meta-analysis
- Published on 07/01/2025
- Reading time: 6 min.
Treviño-Nakoura Ana 1,2, Sepúlveda-Crespo Daniel 3,4, Bellon José M 5, Codina Helena 3, Quero-Delgado Marta 3, Ryan Pablo 4,6, Martínez Isidoro 3,4, Resino Salvador 3,4
1 https://ror.org/005a3p084 Servicio de Medicina Preventiva y Salud Pública Hospital Universitario Nuestra Señora de la Candelaria Santa Cruz de Tenerife Spain
2 Instituto Mixto de Investigación Escuela Nacional de Sanidad-Universidad Nacional de Educación a Distancia (IMIENS-UNED) Madrid Spain
3 Unidad de Infección Viral e Inmunidad, Centro Nacional de Microbiología - Instituto de Salud Carlos III Km 2.2 28220 Majadahonda (Madrid) Spain
4 https://ror.org/00ca2c886 Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC) Instituto de Salud Carlos III Madrid Spain
5 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM) Madrid Spain
6 https://ror.org/05nfzf209 Servicio de Medicina Interna Hospital Universitario Infanta Leonor Madrid Spain
Abstract
Background The current diagnostic strategy for hepatitis C virus (HCV) infection involves a two-step approach: antibody HCV screening followed by confirmatory nucleic acid testing. This study aimed to evaluate the diagnostic performance of the Abbott ARCHITECT HCV Ag assay in serum/plasma samples as a potential one-step alternative for diagnosing active HCV infection in people living with hepatitis B virus (PLWHB) through a systematic review and meta-analysis.
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