Japanese encephalitis virus infection causes reactive oxygen species‐mediated skeletal muscle damage
- Published on 18/02/2025
- Reading time: 7 min.
Gajendra Singh 1, Kulwant Singh 2, Rohit A. Sinha 3, Anjali Singh 1, Khushi 1, Alok Kumar 1
1
Department of Molecular Medicine and Biotechnology
Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)
Lucknow
India
2
Stem Cell Research Center
Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS)
Lucknow
India
3
Department of Endocrinology
Sanjay Gandhi Post Graduate Institute of Medical Sciences
Lucknow
India
Abstract
Skeletal muscle wasting is a clinically proven pathology associated with Japanese encephalitis virus (JEV) infection; however, underlying factors that govern skeletal muscle damage are yet to be explored. The current study aims to investigate the pathobiology of skeletal muscle damage using a mouse model of JEV infection. Our study reveals a significant increment in viral copy number in skeletal muscle post‐JEV infection, which is associated with enhanced skeletal muscle...
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