
Rabies is almost universally fatal if not treated before symptoms appear. Fortunately, post-exposure prophylaxis (PEP) is a nearly 100% effective treatment when started soon after rabies exposure. Nevertheless, rabies causes approximately 59,000 deaths annually, predominantly in rural parts of low- and...

To critically evaluate current and next-generation rabies vaccine technologies and identify major barriers to eliminating rabies, an almost invariably fatal yet vaccine-preventable zoonosis causing ~59,000 deaths annually, mainly in Africa and Asia. A systematic review was undertaken in accordance with...