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Rabies
Potency, immunogenicity, and efficacy of rabies vaccine: In vitro and in vivo approach
The neurotropic rabies virus (RABV), also known as rabies lyssavirus, is the cause of rabies in both people and animals. Rabies can be spread by contact with animal saliva and, less frequently, human saliva. Many mammalian species have been shown to be infected by it in the wild, and in the lab, it has...
Rabies
Immunogenicity and Safety of a Purified Vero Rabies Vaccine – Serum Free, Compared With Two Licensed Vaccines, in a Simulated Rabies Post-Exposure Regimen in Healthy Adults in France: A Randomized Controlled Phase III Trial
A next-generation Vero cell rabies vaccine (PVRV-NG2) was developed using the same Pitman–Moore strain as in the licensed purified Vero cell vaccine (PVRV; Verorab®) and the human diploid cell vaccine (HDCV; Imovax Rabies®). This dual-center, modified double-blind, phase III study in France...
Rabies
Safety and immunogenicity of a ChAd155-vectored rabies vaccine compared with inactivated, purified chick embryo cell rabies vaccine in healthy adults
Rabies is a zoonotic viral encephalitis that is endemic in many countries and confers a high mortality. Licensed vaccines require several doses to ensure efficacy. To investigate a logistically favorable approach, we assessed the safety and immunogenicity of ChAd155-RG, a novel investigational rabies...
Rabies
Epidemiological characteristics of human rabies cases reported by sites in China from 2006 to 2022
Rabies, one of the oldest zoonotic diseases worldwide, is caused by rabies virus and rabies-related lyssaviruses, which are members of the genus Lyssavirus of the family Rhabdoviridae [1]. Dog- mediated rabies is an incessant public health threat in China due to intra- and interspecific...
Rabies
Understanding the journey towards rabies vaccination for travellers: Results of a cross-sectional survey with patients and providers in the US, Germany, Sweden, and Switzerland
Although cases of rabies in international travellers are uncommon, they are a fatal risk which can be alleviated through vaccination prior to travel. As international travel recovers post-COVID, it is vital that travellers are made aware of the risk of rabies when travelling to endemic countries and...
